New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.

Marchais-Oberwinkler, Sandrine

New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases. [electronic resource] - Journal of medicinal chemistry Jan 2011 - 534-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm1009082 doi


17-Hydroxysteroid Dehydrogenases--antagonists & inhibitors
Administration, Oral
Animals
Biological Availability
Cell Line, Tumor
Cell Membrane Permeability
Cell-Free System
Estrogen Receptor alpha--metabolism
Estrogen Receptor beta--metabolism
Estrogens--physiology
Female
Humans
Liver--metabolism
Male
Microsomes--drug effects
Molecular Mimicry
Naphthols--chemical synthesis
Phenols--chemical synthesis
Placenta--enzymology
Pregnancy
Rats
Rats, Sprague-Dawley
Rats, Wistar
Recombinant Proteins--antagonists & inhibitors
Steroids--chemistry
Structure-Activity Relationship