The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. [electronic resource]
Producer: 20110609Description: 101-8 p. digitalISSN:- 1521-0499
- Animals
- Bronchoalveolar Lavage Fluid -- chemistry
- Chemokine CCL2 -- metabolism
- Chemokines, CC -- metabolism
- Chymases -- antagonists & inhibitors
- Cytokines -- metabolism
- Hydroxyproline -- metabolism
- Macrophage Inflammatory Proteins -- metabolism
- Male
- Mast Cells -- drug effects
- Mice
- Mice, Inbred ICR
- Neutrophils -- drug effects
- Pulmonary Fibrosis -- chemically induced
- Serine Endopeptidases -- biosynthesis
- Silicon Dioxide
- Sulfonamides -- pharmacology
- Thiophenes -- pharmacology
- Transforming Growth Factor beta1 -- metabolism
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Publication Type: Journal Article
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