The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice.

Takato, Hazuki

The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. [electronic resource] - Experimental lung research Mar 2011 - 101-8 p. digital

Publication Type: Journal Article

1521-0499

10.3109/01902148.2010.520815 doi


Animals
Bronchoalveolar Lavage Fluid--chemistry
Chemokine CCL2--metabolism
Chemokines, CC--metabolism
Chymases--antagonists & inhibitors
Cytokines--metabolism
Hydroxyproline--metabolism
Macrophage Inflammatory Proteins--metabolism
Male
Mast Cells--drug effects
Mice
Mice, Inbred ICR
Neutrophils--drug effects
Pulmonary Fibrosis--chemically induced
Serine Endopeptidases--biosynthesis
Silicon Dioxide
Sulfonamides--pharmacology
Thiophenes--pharmacology
Transforming Growth Factor beta1--metabolism