Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity. [electronic resource]
Producer: 20110920Description: 375-82 p. digitalISSN:- 1873-1708
- Abnormalities, Drug-Induced -- etiology
- Animal Testing Alternatives
- Animals
- Cell Differentiation -- drug effects
- Cell Line
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Embryo, Mammalian -- drug effects
- Embryonic Stem Cells -- drug effects
- Gene Expression Regulation, Developmental -- drug effects
- Immunohistochemistry
- Mice
- Molecular Structure
- Myocardial Contraction -- drug effects
- Myocytes, Cardiac -- drug effects
- Neural Tube Defects -- chemically induced
- Reverse Transcriptase Polymerase Chain Reaction
- Risk Assessment
- Structure-Activity Relationship
- Time Factors
- Toxicity Tests
- Valproic Acid -- analogs & derivatives
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
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