Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity.

de Jong, E

Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity. [electronic resource] - Reproductive toxicology (Elmsford, N.Y.) May 2011 - 375-82 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review

1873-1708

10.1016/j.reprotox.2010.11.012 doi


Abnormalities, Drug-Induced--etiology
Animal Testing Alternatives
Animals
Cell Differentiation--drug effects
Cell Line
Cell Survival--drug effects
Dose-Response Relationship, Drug
Embryo, Mammalian--drug effects
Embryonic Stem Cells--drug effects
Gene Expression Regulation, Developmental--drug effects
Immunohistochemistry
Mice
Molecular Structure
Myocardial Contraction--drug effects
Myocytes, Cardiac--drug effects
Neural Tube Defects--chemically induced
Reverse Transcriptase Polymerase Chain Reaction
Risk Assessment
Structure-Activity Relationship
Time Factors
Toxicity Tests
Valproic Acid--analogs & derivatives