FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. [electronic resource]
Producer: 20110224Description: 8-15 p. digitalISSN:- 1096-0333
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Bcl-2-Like Protein 11
- Carcinoma, Squamous Cell -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cisplatin -- pharmacology
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Dose-Response Relationship, Drug
- Drug Synergism
- Forkhead Box Protein O3
- Forkhead Transcription Factors -- genetics
- Humans
- Male
- Membrane Proteins -- metabolism
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Molecular Targeted Therapy
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- S-Phase Kinase-Associated Proteins -- metabolism
- Sirolimus -- pharmacology
- Time Factors
- Tongue Neoplasms -- drug therapy
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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