FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells.

Fang, Liang

FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. [electronic resource] - Toxicology and applied pharmacology Feb 2011 - 8-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0333

10.1016/j.taap.2010.11.007 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Bcl-2-Like Protein 11
Carcinoma, Squamous Cell--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p27--metabolism
Dose-Response Relationship, Drug
Drug Synergism
Forkhead Box Protein O3
Forkhead Transcription Factors--genetics
Humans
Male
Membrane Proteins--metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Targeted Therapy
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
S-Phase Kinase-Associated Proteins--metabolism
Sirolimus--pharmacology
Time Factors
Tongue Neoplasms--drug therapy
Tumor Burden--drug effects
Xenograft Model Antitumor Assays