The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. [electronic resource]
Producer: 20110425Description: 26-30 p. digitalISSN:- 1872-7972
- Age Factors
- Animals
- Animals, Newborn
- Apoptosis -- drug effects
- Avoidance Learning -- drug effects
- Bromodeoxyuridine -- metabolism
- Carbolines -- pharmacology
- Caspase 3 -- metabolism
- Cell Proliferation -- drug effects
- DNA Fragmentation -- drug effects
- Dentate Gyrus -- cytology
- Depression -- drug therapy
- Disease Models, Animal
- Female
- Freezing Reaction, Cataleptic -- drug effects
- In Situ Nick-End Labeling
- Maternal Deprivation
- Memory Disorders -- drug therapy
- Phosphodiesterase 5 Inhibitors -- pharmacology
- Pregnancy
- Rats
- Rats, Sprague-Dawley
- Reaction Time -- drug effects
- Swimming -- psychology
- Tadalafil
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Publication Type: Journal Article
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