The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups.

Baek, Sang-Bin

The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. [electronic resource] - Neuroscience letters Jan 2011 - 26-30 p. digital

Publication Type: Journal Article

1872-7972

10.1016/j.neulet.2010.10.074 doi


Age Factors
Animals
Animals, Newborn
Apoptosis--drug effects
Avoidance Learning--drug effects
Bromodeoxyuridine--metabolism
Carbolines--pharmacology
Caspase 3--metabolism
Cell Proliferation--drug effects
DNA Fragmentation--drug effects
Dentate Gyrus--cytology
Depression--drug therapy
Disease Models, Animal
Female
Freezing Reaction, Cataleptic--drug effects
In Situ Nick-End Labeling
Maternal Deprivation
Memory Disorders--drug therapy
Phosphodiesterase 5 Inhibitors--pharmacology
Pregnancy
Rats
Rats, Sprague-Dawley
Reaction Time--drug effects
Swimming--psychology
Tadalafil