Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. [electronic resource]
Producer: 20110705Description: 30-8 p. digitalISSN:- 1521-009X
- Astemizole -- pharmacology
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 Enzyme System -- metabolism
- Humans
- Hydroxylation
- Ketoconazole -- pharmacology
- Lactones -- blood
- Microsomes -- metabolism
- Microsomes, Liver -- metabolism
- Pyridines -- blood
- Receptor, PAR-1 -- metabolism
- Receptors, Thrombin -- antagonists & inhibitors
- Recombinant Proteins -- metabolism
- Tranylcypromine -- pharmacology
- Platelet Aggregation Inhibitors
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Publication Type: Journal Article
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