Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.

Ghosal, Anima

Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Jan 2011 - 30-8 p. digital

Publication Type: Journal Article

1521-009X

10.1124/dmd.110.035493 doi


Astemizole--pharmacology
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 Enzyme System--metabolism
Humans
Hydroxylation
Ketoconazole--pharmacology
Lactones--blood
Microsomes--metabolism
Microsomes, Liver--metabolism
Pyridines--blood
Receptor, PAR-1--metabolism
Receptors, Thrombin--antagonists & inhibitors
Recombinant Proteins--metabolism
Tranylcypromine--pharmacology
Platelet Aggregation Inhibitors