Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. [electronic resource]
Producer: 20101228Description: 127 p. digitalISSN:- 1756-9966
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Blotting, Western
- Cell Adhesion -- drug effects
- Cell Movement -- drug effects
- Cell Survival -- drug effects
- Extracellular Matrix Proteins -- metabolism
- Fatty Acids, Monounsaturated -- pharmacology
- Female
- Fluvastatin
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- administration & dosage
- Indoles -- pharmacology
- Integrins -- metabolism
- Lim Kinases -- metabolism
- Lung Neoplasms -- enzymology
- Matrix Metalloproteinases -- genetics
- Melanoma, Experimental -- drug therapy
- Mice
- Mice, Inbred C57BL
- Myosin Light Chains -- metabolism
- Neoplasm Invasiveness
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Simvastatin -- pharmacology
- Time Factors
- rho GTP-Binding Proteins -- metabolism
- rho-Associated Kinases -- antagonists & inhibitors
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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