Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.

Kidera, Yasuhiro

Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. [electronic resource] - Journal of experimental & clinical cancer research : CR Sep 2010 - 127 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1756-9966

10.1186/1756-9966-29-127 doi


Administration, Oral
Animals
Antineoplastic Agents--administration & dosage
Blotting, Western
Cell Adhesion--drug effects
Cell Movement--drug effects
Cell Survival--drug effects
Extracellular Matrix Proteins--metabolism
Fatty Acids, Monounsaturated--pharmacology
Female
Fluvastatin
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Hydroxymethylglutaryl-CoA Reductase Inhibitors--administration & dosage
Indoles--pharmacology
Integrins--metabolism
Lim Kinases--metabolism
Lung Neoplasms--enzymology
Matrix Metalloproteinases--genetics
Melanoma, Experimental--drug therapy
Mice
Mice, Inbred C57BL
Myosin Light Chains--metabolism
Neoplasm Invasiveness
Phosphorylation
Protein Kinase Inhibitors--pharmacology
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Simvastatin--pharmacology
Time Factors
rho GTP-Binding Proteins--metabolism
rho-Associated Kinases--antagonists & inhibitors