The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. [electronic resource]
Producer: 20110414Description: 133-44 p. digitalISSN:- 1476-5403
- Activating Transcription Factor 4 -- metabolism
- Activating Transcription Factor 6 -- metabolism
- Animals
- Apoptosis
- Cell Line
- DNA-Binding Proteins -- metabolism
- Endoplasmic Reticulum -- metabolism
- Humans
- Leupeptins -- pharmacology
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Monomeric GTP-Binding Proteins -- metabolism
- Multiprotein Complexes
- Mutation
- Neuropeptides -- metabolism
- Phosphorylation
- Proteins -- metabolism
- Ras Homolog Enriched in Brain Protein
- TOR Serine-Threonine Kinases
- Transcription Factor CHOP -- metabolism
- Transcription Factors -- metabolism
- Tuberous Sclerosis Complex 1 Protein
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- genetics
- Unfolded Protein Response -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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