The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.

Kang, Y J

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. [electronic resource] - Cell death and differentiation Jan 2011 - 133-44 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1476-5403

10.1038/cdd.2010.82 doi


Activating Transcription Factor 4--metabolism
Activating Transcription Factor 6--metabolism
Animals
Apoptosis
Cell Line
DNA-Binding Proteins--metabolism
Endoplasmic Reticulum--metabolism
Humans
Leupeptins--pharmacology
Mechanistic Target of Rapamycin Complex 1
Mice
Monomeric GTP-Binding Proteins--metabolism
Multiprotein Complexes
Mutation
Neuropeptides--metabolism
Phosphorylation
Proteins--metabolism
Ras Homolog Enriched in Brain Protein
TOR Serine-Threonine Kinases
Transcription Factor CHOP--metabolism
Transcription Factors--metabolism
Tuberous Sclerosis Complex 1 Protein
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--genetics
Unfolded Protein Response--physiology