The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta. [electronic resource]
Producer: 20101228Description: 100-6 p. digitalISSN:- 1879-1484
- Androgen Antagonists -- pharmacology
- Androstane-3,17-diol -- administration & dosage
- Animals
- Anti-Inflammatory Agents -- administration & dosage
- Aorta -- drug effects
- Endothelial Cells -- drug effects
- Estrogen Antagonists -- pharmacology
- Gene Expression Profiling -- methods
- Gene Expression Regulation -- drug effects
- Humans
- Inflammation -- genetics
- Inflammation Mediators -- metabolism
- Lipopolysaccharides -- pharmacology
- Macrophages -- drug effects
- Male
- Mice
- Mice, Inbred C57BL
- Oligonucleotide Array Sequence Analysis
- Orchiectomy
- Protein Array Analysis
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha -- metabolism
- U937 Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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