The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta.

Norata, Giuseppe Danilo

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta. [electronic resource] - Atherosclerosis Sep 2010 - 100-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-1484

10.1016/j.atherosclerosis.2010.05.015 doi


Androgen Antagonists--pharmacology
Androstane-3,17-diol--administration & dosage
Animals
Anti-Inflammatory Agents--administration & dosage
Aorta--drug effects
Endothelial Cells--drug effects
Estrogen Antagonists--pharmacology
Gene Expression Profiling--methods
Gene Expression Regulation--drug effects
Humans
Inflammation--genetics
Inflammation Mediators--metabolism
Lipopolysaccharides--pharmacology
Macrophages--drug effects
Male
Mice
Mice, Inbred C57BL
Oligonucleotide Array Sequence Analysis
Orchiectomy
Protein Array Analysis
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha--metabolism
U937 Cells