Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. [electronic resource]
Producer: 20100817Description: 547-59 p. digitalISSN:- 1878-3686
- AMP-Activated Protein Kinase Kinases
- AMP-Activated Protein Kinases
- Animals
- Carcinoma, Non-Small-Cell Lung -- genetics
- Cell Adhesion -- genetics
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Transdifferentiation -- genetics
- Drug Therapy, Combination
- Enzyme Inhibitors -- therapeutic use
- Female
- Focal Adhesion Protein-Tyrosine Kinases -- antagonists & inhibitors
- Focal Adhesions -- genetics
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic -- genetics
- Genomics
- Humans
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Lung Neoplasms -- drug therapy
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- MAP Kinase Kinase 2 -- antagonists & inhibitors
- Mice
- Mice, Mutant Strains
- Mice, Nude
- Neoplasm Metastasis -- drug therapy
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proteomics
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins p21(ras) -- genetics
- RNA Interference
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases
- Up-Regulation -- genetics
- Xenograft Model Antitumor Assays
- ras Proteins -- genetics
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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