Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.

Carretero, Julian

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. [electronic resource] - Cancer cell Jun 2010 - 547-59 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1878-3686

10.1016/j.ccr.2010.04.026 doi


AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Animals
Carcinoma, Non-Small-Cell Lung--genetics
Cell Adhesion--genetics
Cell Line, Tumor
Cell Movement--genetics
Cell Transdifferentiation--genetics
Drug Therapy, Combination
Enzyme Inhibitors--therapeutic use
Female
Focal Adhesion Protein-Tyrosine Kinases--antagonists & inhibitors
Focal Adhesions--genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic--genetics
Genomics
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lung Neoplasms--drug therapy
MAP Kinase Kinase 1--antagonists & inhibitors
MAP Kinase Kinase 2--antagonists & inhibitors
Mice
Mice, Mutant Strains
Mice, Nude
Neoplasm Metastasis--drug therapy
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation--genetics
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
Proteomics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins p21(ras)--genetics
RNA Interference
Signal Transduction--drug effects
TOR Serine-Threonine Kinases
Up-Regulation--genetics
Xenograft Model Antitumor Assays
ras Proteins--genetics
src-Family Kinases--antagonists & inhibitors