The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. [electronic resource]
Producer: 20100903Description: 4567-75 p. digitalISSN:- 1476-5594
- Adenoma -- enzymology
- Adenomatous Polyposis Coli Protein -- metabolism
- Alleles
- Animals
- Cell Differentiation -- genetics
- Cell Proliferation
- Chromogranins
- Colorectal Neoplasms -- enzymology
- Cyclic AMP -- metabolism
- Disease Progression
- Epithelial Cells -- metabolism
- Female
- GTP-Binding Protein alpha Subunits, Gs -- genetics
- Gene Expression Regulation, Neoplastic
- Genetic Loci -- genetics
- Humans
- Intestinal Mucosa -- metabolism
- MAP Kinase Signaling System
- Male
- Membrane Glycoproteins -- genetics
- Mice
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Mutant Proteins -- genetics
- Mutation
- Organ Specificity
- Phosphoric Diester Hydrolases -- metabolism
- Promoter Regions, Genetic -- genetics
- Stem Cells -- metabolism
- Substrate Specificity
- Up-Regulation
- Wnt Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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