The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.

Wilson, C H

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. [electronic resource] - Oncogene Aug 2010 - 4567-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5594

10.1038/onc.2010.202 doi


Adenoma--enzymology
Adenomatous Polyposis Coli Protein--metabolism
Alleles
Animals
Cell Differentiation--genetics
Cell Proliferation
Chromogranins
Colorectal Neoplasms--enzymology
Cyclic AMP--metabolism
Disease Progression
Epithelial Cells--metabolism
Female
GTP-Binding Protein alpha Subunits, Gs--genetics
Gene Expression Regulation, Neoplastic
Genetic Loci--genetics
Humans
Intestinal Mucosa--metabolism
MAP Kinase Signaling System
Male
Membrane Glycoproteins--genetics
Mice
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Mutant Proteins--genetics
Mutation
Organ Specificity
Phosphoric Diester Hydrolases--metabolism
Promoter Regions, Genetic--genetics
Stem Cells--metabolism
Substrate Specificity
Up-Regulation
Wnt Proteins--metabolism