A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. [electronic resource]
Producer: 20101004Description: 18-30 p. digitalISSN:- 1872-7980
- Abietanes
- Animals
- Antineoplastic Agents, Phytogenic -- chemical synthesis
- Antioxidants -- pharmacology
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cytochromes c -- metabolism
- Dose-Response Relationship, Drug
- Doxorubicin -- pharmacology
- Female
- HL-60 Cells
- HeLa Cells
- Hep G2 Cells
- Humans
- Inhibitory Concentration 50
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mitochondria -- drug effects
- Neoplasms -- drug therapy
- Paclitaxel -- pharmacology
- Phenanthrenes -- chemical synthesis
- Propyl Gallate -- pharmacology
- Protein Transport
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Reactive Oxygen Species -- metabolism
- Receptor, ErbB-2 -- metabolism
- Solubility
- Time Factors
- Transfection
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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