A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway.

Tian, Hong-Lei

A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. [electronic resource] - Cancer letters Nov 2010 - 18-30 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-7980

10.1016/j.canlet.2010.04.020 doi


Abietanes
Animals
Antineoplastic Agents, Phytogenic--chemical synthesis
Antioxidants--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Cell Proliferation--drug effects
Cell Survival--drug effects
Cytochromes c--metabolism
Dose-Response Relationship, Drug
Doxorubicin--pharmacology
Female
HL-60 Cells
HeLa Cells
Hep G2 Cells
Humans
Inhibitory Concentration 50
Mice
Mice, Inbred BALB C
Mice, Nude
Mitochondria--drug effects
Neoplasms--drug therapy
Paclitaxel--pharmacology
Phenanthrenes--chemical synthesis
Propyl Gallate--pharmacology
Protein Transport
Proto-Oncogene Proteins c-bcl-2--genetics
Reactive Oxygen Species--metabolism
Receptor, ErbB-2--metabolism
Solubility
Time Factors
Transfection
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
bcl-2-Associated X Protein--metabolism