The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. [electronic resource]
Producer: 20110321Description: 1795-804 p. digitalISSN:- 1476-5403
- 3-Phosphoinositide-Dependent Protein Kinases
- Acenaphthenes -- metabolism
- Animals
- Apoptosis
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Epidermal Growth Factor -- metabolism
- Fluorescent Antibody Technique
- Gene Amplification
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Magnetic Resonance Spectroscopy
- Membrane Proteins -- metabolism
- Phosphoproteins -- chemistry
- Phosphorylation -- drug effects
- Polymerase Chain Reaction
- Protein Serine-Threonine Kinases -- metabolism
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt -- chemistry
- Ribonucleotides -- metabolism
- Signal Transduction
- Surface Plasmon Resonance
- TOR Serine-Threonine Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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