Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. [electronic resource]
Producer: 20100617Description: 4460-9 p. digitalISSN:- 1538-7445
- Adaptor Proteins, Signal Transducing -- biosynthesis
- Animals
- Cell Cycle Proteins -- biosynthesis
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cyclin-Dependent Kinase 5 -- antagonists & inhibitors
- Down-Regulation
- Gene Knockdown Techniques
- Humans
- MAP Kinase Signaling System -- drug effects
- Mice
- Pancreatic Neoplasms -- enzymology
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Signal Transduction
- Xenograft Model Antitumor Assays
- ral GTP-Binding Proteins -- antagonists & inhibitors
- ras Proteins -- antagonists & inhibitors
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.