Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling.
Feldmann, Georg
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. [electronic resource] - Cancer research Jun 2010 - 4460-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-09-1107 doi
Adaptor Proteins, Signal Transducing--biosynthesis
Animals
Cell Cycle Proteins--biosynthesis
Cell Growth Processes--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cyclin-Dependent Kinase 5--antagonists & inhibitors
Down-Regulation
Gene Knockdown Techniques
Humans
MAP Kinase Signaling System--drug effects
Mice
Pancreatic Neoplasms--enzymology
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction
Xenograft Model Antitumor Assays
ral GTP-Binding Proteins--antagonists & inhibitors
ras Proteins--antagonists & inhibitors
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. [electronic resource] - Cancer research Jun 2010 - 4460-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-09-1107 doi
Adaptor Proteins, Signal Transducing--biosynthesis
Animals
Cell Cycle Proteins--biosynthesis
Cell Growth Processes--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cyclin-Dependent Kinase 5--antagonists & inhibitors
Down-Regulation
Gene Knockdown Techniques
Humans
MAP Kinase Signaling System--drug effects
Mice
Pancreatic Neoplasms--enzymology
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction
Xenograft Model Antitumor Assays
ral GTP-Binding Proteins--antagonists & inhibitors
ras Proteins--antagonists & inhibitors