Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. [electronic resource]
Producer: 20100826Description: 418-26 p. digitalISSN:- 1365-2567
- Apoptosis -- drug effects
- Butadienes -- pharmacology
- CD4-Positive T-Lymphocytes -- cytology
- Caspase 3 -- metabolism
- Caspase Inhibitors
- Cell Survival -- drug effects
- Chromones -- pharmacology
- Cytokines -- deficiency
- Enzyme Inhibitors -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Humans
- Immunologic Memory -- drug effects
- Interleukin-2 -- pharmacology
- Interleukin-7 -- immunology
- Interleukin-7 Receptor alpha Subunit -- metabolism
- Janus Kinases -- antagonists & inhibitors
- Leukocyte Common Antigens -- metabolism
- Lymphocyte Activation -- immunology
- Morpholines -- pharmacology
- Myeloid Cell Leukemia Sequence 1 Protein
- Nitriles -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- STAT Transcription Factors -- metabolism
- STAT5 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Up-Regulation -- drug effects
- bcl-X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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