Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway.

Chetoui, Nizar

Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. [electronic resource] - Immunology Jul 2010 - 418-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1365-2567

10.1111/j.1365-2567.2009.03244.x doi


Apoptosis--drug effects
Butadienes--pharmacology
CD4-Positive T-Lymphocytes--cytology
Caspase 3--metabolism
Caspase Inhibitors
Cell Survival--drug effects
Chromones--pharmacology
Cytokines--deficiency
Enzyme Inhibitors--pharmacology
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Humans
Immunologic Memory--drug effects
Interleukin-2--pharmacology
Interleukin-7--immunology
Interleukin-7 Receptor alpha Subunit--metabolism
Janus Kinases--antagonists & inhibitors
Leukocyte Common Antigens--metabolism
Lymphocyte Activation--immunology
Morpholines--pharmacology
Myeloid Cell Leukemia Sequence 1 Protein
Nitriles--pharmacology
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
STAT Transcription Factors--metabolism
STAT5 Transcription Factor--metabolism
Signal Transduction--drug effects
Up-Regulation--drug effects
bcl-X Protein--metabolism