Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. [electronic resource]
Producer: 20100629Description: 9879-84 p. digitalISSN:- 1091-6490
- Aging
- Animals
- Apoptosis
- Autophagy
- Dopamine -- metabolism
- Homeostasis
- Kidney Diseases -- genetics
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes -- metabolism
- Mice
- Mice, Knockout
- Oxidation-Reduction
- Protein Serine-Threonine Kinases -- deficiency
- Ubiquitination
- alpha-Synuclein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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