Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Tong, Youren
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America May 2010 - 9879-84 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1004676107 doi
Aging
Animals
Apoptosis
Autophagy
Dopamine--metabolism
Homeostasis
Kidney Diseases--genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lysosomes--metabolism
Mice
Mice, Knockout
Oxidation-Reduction
Protein Serine-Threonine Kinases--deficiency
Ubiquitination
alpha-Synuclein--metabolism
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America May 2010 - 9879-84 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1004676107 doi
Aging
Animals
Apoptosis
Autophagy
Dopamine--metabolism
Homeostasis
Kidney Diseases--genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lysosomes--metabolism
Mice
Mice, Knockout
Oxidation-Reduction
Protein Serine-Threonine Kinases--deficiency
Ubiquitination
alpha-Synuclein--metabolism