Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. [electronic resource]
Producer: 20100921Description: 2867-77 p. digitalISSN:- 1098-6596
- Bacterial Proteins -- metabolism
- Cephalosporinase -- metabolism
- Clavulanic Acid -- pharmacology
- Computer Simulation
- Enzyme Inhibitors -- chemistry
- Hydrogen Bonding
- Kinetics
- Microbial Sensitivity Tests
- Molecular Structure
- Mutagenesis, Site-Directed
- Penicillanic Acid -- analogs & derivatives
- Protein Structure, Secondary
- Spectrometry, Mass, Electrospray Ionization
- Substrate Specificity
- Sulbactam -- pharmacology
- Tazobactam
- beta-Lactamase Inhibitors
- beta-Lactamases -- chemistry
- beta-Lactams -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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