Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
Papp-Wallace, Krisztina M
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. [electronic resource] - Antimicrobial agents and chemotherapy Jul 2010 - 2867-77 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1098-6596
10.1128/AAC.00197-10 doi
Bacterial Proteins--metabolism
Cephalosporinase--metabolism
Clavulanic Acid--pharmacology
Computer Simulation
Enzyme Inhibitors--chemistry
Hydrogen Bonding
Kinetics
Microbial Sensitivity Tests
Molecular Structure
Mutagenesis, Site-Directed
Penicillanic Acid--analogs & derivatives
Protein Structure, Secondary
Spectrometry, Mass, Electrospray Ionization
Substrate Specificity
Sulbactam--pharmacology
Tazobactam
beta-Lactamase Inhibitors
beta-Lactamases--chemistry
beta-Lactams--chemistry
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. [electronic resource] - Antimicrobial agents and chemotherapy Jul 2010 - 2867-77 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1098-6596
10.1128/AAC.00197-10 doi
Bacterial Proteins--metabolism
Cephalosporinase--metabolism
Clavulanic Acid--pharmacology
Computer Simulation
Enzyme Inhibitors--chemistry
Hydrogen Bonding
Kinetics
Microbial Sensitivity Tests
Molecular Structure
Mutagenesis, Site-Directed
Penicillanic Acid--analogs & derivatives
Protein Structure, Secondary
Spectrometry, Mass, Electrospray Ionization
Substrate Specificity
Sulbactam--pharmacology
Tazobactam
beta-Lactamase Inhibitors
beta-Lactamases--chemistry
beta-Lactams--chemistry