Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. [electronic resource]
Producer: 20100824Description: 71-80 p. digitalISSN:- 1528-0020
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Apoptosis -- drug effects
- Cell Cycle Proteins
- Cell Line, Tumor
- Cells, Cultured
- Drug Resistance, Neoplasm -- drug effects
- Female
- Flow Cytometry
- Humans
- Imidazoles -- pharmacology
- Immunoblotting
- Indoles -- pharmacology
- Leukemia, Myeloid -- genetics
- Male
- Middle Aged
- Nuclear Proteins -- genetics
- Piperazines -- pharmacology
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Spiro Compounds -- pharmacology
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
- Young Adult
- fms-Like Tyrosine Kinase 3 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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