Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.

Long, Jianting

Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. [electronic resource] - Blood Jul 2010 - 71-80 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0020

10.1182/blood-2010-01-261628 doi


Acute Disease
Adult
Aged
Aged, 80 and over
Apoptosis--drug effects
Cell Cycle Proteins
Cell Line, Tumor
Cells, Cultured
Drug Resistance, Neoplasm--drug effects
Female
Flow Cytometry
Humans
Imidazoles--pharmacology
Immunoblotting
Indoles--pharmacology
Leukemia, Myeloid--genetics
Male
Middle Aged
Nuclear Proteins--genetics
Piperazines--pharmacology
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Spiro Compounds--pharmacology
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics
Young Adult
fms-Like Tyrosine Kinase 3--genetics