Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. [electronic resource]
Producer: 20101028Description: 452-66 p. digitalISSN:- 1096-0929
- Animals
- Aryl Hydrocarbon Hydroxylases -- biosynthesis
- Cell Proliferation -- drug effects
- Chlordan -- toxicity
- Constitutive Androstane Receptor
- Cytochrome P-450 CYP3A -- biosynthesis
- Cytochrome P450 Family 2
- Humans
- Hyperplasia
- Hypertrophy
- Liver -- drug effects
- Liver Neoplasms, Experimental -- chemically induced
- Membrane Proteins -- biosynthesis
- Mice
- Mice, Inbred C57BL
- Phenobarbital -- toxicity
- Pregnane X Receptor
- Receptors, Cytoplasmic and Nuclear -- physiology
- Receptors, Steroid -- physiology
- Species Specificity
- Steroid Hydroxylases -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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