Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Ross, Jillian

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Aug 2010 - 452-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0929

10.1093/toxsci/kfq118 doi


Animals
Aryl Hydrocarbon Hydroxylases--biosynthesis
Cell Proliferation--drug effects
Chlordan--toxicity
Constitutive Androstane Receptor
Cytochrome P-450 CYP3A--biosynthesis
Cytochrome P450 Family 2
Humans
Hyperplasia
Hypertrophy
Liver--drug effects
Liver Neoplasms, Experimental--chemically induced
Membrane Proteins--biosynthesis
Mice
Mice, Inbred C57BL
Phenobarbital--toxicity
Pregnane X Receptor
Receptors, Cytoplasmic and Nuclear--physiology
Receptors, Steroid--physiology
Species Specificity
Steroid Hydroxylases--biosynthesis