MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression. [electronic resource]
Producer: 20100518Description: 703-11 p. digitalISSN:- 1791-7530
- Animals
- Becaplermin
- Carcinoma, Squamous Cell -- blood supply
- Cell Line, Tumor
- Collagen -- metabolism
- Fibroblasts -- enzymology
- Humans
- Matrix Metalloproteinases, Secreted -- antagonists & inhibitors
- Mice
- Mice, Nude
- Neoplasm Invasiveness
- Organic Chemicals -- pharmacology
- Piperazines -- pharmacology
- Platelet-Derived Growth Factor -- biosynthesis
- Proto-Oncogene Proteins c-sis
- Pyrimidines -- pharmacology
- Skin Neoplasms -- blood supply
- Tissue Inhibitor of Metalloproteinase-1 -- biosynthesis
- Tissue Inhibitor of Metalloproteinase-2 -- biosynthesis
- Vascular Endothelial Growth Factor A -- biosynthesis
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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