MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression.

Woenne, Eva C

MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression. [electronic resource] - Anticancer research Mar 2010 - 703-11 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1791-7530


Animals
Becaplermin
Carcinoma, Squamous Cell--blood supply
Cell Line, Tumor
Collagen--metabolism
Fibroblasts--enzymology
Humans
Matrix Metalloproteinases, Secreted--antagonists & inhibitors
Mice
Mice, Nude
Neoplasm Invasiveness
Organic Chemicals--pharmacology
Piperazines--pharmacology
Platelet-Derived Growth Factor--biosynthesis
Proto-Oncogene Proteins c-sis
Pyrimidines--pharmacology
Skin Neoplasms--blood supply
Tissue Inhibitor of Metalloproteinase-1--biosynthesis
Tissue Inhibitor of Metalloproteinase-2--biosynthesis
Vascular Endothelial Growth Factor A--biosynthesis
Xenograft Model Antitumor Assays