Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40. [electronic resource]
Producer: 20100701Description: 22 p. digitalISSN:- 1742-2094
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- physiology
- Blotting, Western
- Brain Chemistry -- physiology
- Cell Adhesion -- physiology
- Cell Line
- Cerebrovascular Circulation -- physiology
- Collagen Type I -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Humans
- Immunoprecipitation
- Inflammation -- pathology
- Interleukin-1beta -- metabolism
- Peptide Fragments -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein-Tyrosine Kinases -- physiology
- RNA, Small Interfering
- Signal Transduction -- physiology
- Transfection
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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