Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. [electronic resource]
Producer: 20100917Description: 789-800 p. digitalISSN:- 1521-009X
- Adult
- Anti-HIV Agents -- adverse effects
- Area Under Curve
- Biocatalysis
- Cytochrome P-450 CYP3A -- metabolism
- Dealkylation
- Feces -- chemistry
- Glucuronidase -- metabolism
- Glucuronides -- analysis
- Glucuronosyltransferase -- metabolism
- Humans
- Hydrolysis
- Hydroxylation
- Kinetics
- Male
- Microsomes, Liver -- enzymology
- Middle Aged
- Molecular Structure
- Nitriles -- adverse effects
- Oxidation-Reduction
- Pyrazoles -- adverse effects
- Recombinant Proteins -- metabolism
- Reverse Transcriptase Inhibitors -- adverse effects
- Sulfates -- metabolism
- Tandem Mass Spectrometry
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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