Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers.
Vourvahis, Manoli
Excretion and metabolism of lersivirine (5-benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2010 - 789-800 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.109.031252 doi
Adult
Anti-HIV Agents--adverse effects
Area Under Curve
Biocatalysis
Cytochrome P-450 CYP3A--metabolism
Dealkylation
Feces--chemistry
Glucuronidase--metabolism
Glucuronides--analysis
Glucuronosyltransferase--metabolism
Humans
Hydrolysis
Hydroxylation
Kinetics
Male
Microsomes, Liver--enzymology
Middle Aged
Molecular Structure
Nitriles--adverse effects
Oxidation-Reduction
Pyrazoles--adverse effects
Recombinant Proteins--metabolism
Reverse Transcriptase Inhibitors--adverse effects
Sulfates--metabolism
Tandem Mass Spectrometry
Excretion and metabolism of lersivirine (5-benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2010 - 789-800 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.109.031252 doi
Adult
Anti-HIV Agents--adverse effects
Area Under Curve
Biocatalysis
Cytochrome P-450 CYP3A--metabolism
Dealkylation
Feces--chemistry
Glucuronidase--metabolism
Glucuronides--analysis
Glucuronosyltransferase--metabolism
Humans
Hydrolysis
Hydroxylation
Kinetics
Male
Microsomes, Liver--enzymology
Middle Aged
Molecular Structure
Nitriles--adverse effects
Oxidation-Reduction
Pyrazoles--adverse effects
Recombinant Proteins--metabolism
Reverse Transcriptase Inhibitors--adverse effects
Sulfates--metabolism
Tandem Mass Spectrometry