Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis. [electronic resource]
Producer: 20100329Description: 478-88 p. digitalISSN:- 0004-3591
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use
- Celecoxib
- Cells, Cultured
- Chondrocytes -- cytology
- Cyclooxygenase 2 Inhibitors -- therapeutic use
- Dinoprostone -- metabolism
- Dose-Response Relationship, Drug
- Gene Expression -- drug effects
- Humans
- Immunohistochemistry
- Osteoarthritis, Knee -- drug therapy
- Osteoprotegerin -- genetics
- Pyrazoles -- therapeutic use
- RANK Ligand -- genetics
- Receptors, Prostaglandin E -- agonists
- Severity of Illness Index
- Signal Transduction -- drug effects
- Sulfonamides -- therapeutic use
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Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
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