Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.
Moreno-Rubio, Juan
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis. [electronic resource] - Arthritis and rheumatism Feb 2010 - 478-88 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
0004-3591
10.1002/art.27204 doi
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal--therapeutic use
Celecoxib
Cells, Cultured
Chondrocytes--cytology
Cyclooxygenase 2 Inhibitors--therapeutic use
Dinoprostone--metabolism
Dose-Response Relationship, Drug
Gene Expression--drug effects
Humans
Immunohistochemistry
Osteoarthritis, Knee--drug therapy
Osteoprotegerin--genetics
Pyrazoles--therapeutic use
RANK Ligand--genetics
Receptors, Prostaglandin E--agonists
Severity of Illness Index
Signal Transduction--drug effects
Sulfonamides--therapeutic use
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis. [electronic resource] - Arthritis and rheumatism Feb 2010 - 478-88 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
0004-3591
10.1002/art.27204 doi
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal--therapeutic use
Celecoxib
Cells, Cultured
Chondrocytes--cytology
Cyclooxygenase 2 Inhibitors--therapeutic use
Dinoprostone--metabolism
Dose-Response Relationship, Drug
Gene Expression--drug effects
Humans
Immunohistochemistry
Osteoarthritis, Knee--drug therapy
Osteoprotegerin--genetics
Pyrazoles--therapeutic use
RANK Ligand--genetics
Receptors, Prostaglandin E--agonists
Severity of Illness Index
Signal Transduction--drug effects
Sulfonamides--therapeutic use