Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. [electronic resource]
Producer: 20100917Description: 871-8 p. digitalISSN:- 1521-009X
- Animal Structures -- metabolism
- Animals
- Anti-HIV Agents -- blood
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Biocatalysis -- drug effects
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP2D6 -- genetics
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP3A -- genetics
- Cytochrome P-450 CYP3A Inhibitors
- Dealkylation
- Drug Interactions
- Feces -- chemistry
- Humans
- Hydroxylation
- Metabolomics -- methods
- Mice
- Mice, Inbred Strains
- Microsomes, Liver -- drug effects
- Molecular Structure
- Oxidation-Reduction
- Principal Component Analysis
- Pyridines -- blood
- Pyrones -- blood
- Recombinant Proteins -- metabolism
- Ritonavir -- pharmacology
- Spectrometry, Mass, Electrospray Ionization
- Sulfonamides
- Tissue Distribution -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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