Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice.

Li, Feng

Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2010 - 871-8 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1521-009X

10.1124/dmd.109.030817 doi


Animal Structures--metabolism
Animals
Anti-HIV Agents--blood
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biocatalysis--drug effects
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP2D6--genetics
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A--genetics
Cytochrome P-450 CYP3A Inhibitors
Dealkylation
Drug Interactions
Feces--chemistry
Humans
Hydroxylation
Metabolomics--methods
Mice
Mice, Inbred Strains
Microsomes, Liver--drug effects
Molecular Structure
Oxidation-Reduction
Principal Component Analysis
Pyridines--blood
Pyrones--blood
Recombinant Proteins--metabolism
Ritonavir--pharmacology
Spectrometry, Mass, Electrospray Ionization
Sulfonamides
Tissue Distribution--drug effects