Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. [electronic resource]
Producer: 20100806Description: 2406-16 p. digitalISSN:- 1555-8576
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Benzenesulfonates -- pharmacology
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Female
- Humans
- Lung Neoplasms -- metabolism
- Mesothelioma -- metabolism
- Mice
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Transplantation
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Phosphorylation
- Pleural Neoplasms -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Pyridines -- pharmacology
- Sorafenib
- TNF-Related Apoptosis-Inducing Ligand -- metabolism
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Publication Type: Journal Article
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