Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma.
Katz, Sharyn I
Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. [electronic resource] - Cancer biology & therapy Dec 2009 - 2406-16 p. digital
Publication Type: Journal Article
1555-8576
10.4161/cbt.8.24.10824 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis
Benzenesulfonates--pharmacology
Caspase 3--metabolism
Cell Line, Tumor
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Female
Humans
Lung Neoplasms--metabolism
Mesothelioma--metabolism
Mice
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Transplantation
Niacinamide--analogs & derivatives
Phenylurea Compounds
Phosphorylation
Pleural Neoplasms--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Pyridines--pharmacology
Sorafenib
TNF-Related Apoptosis-Inducing Ligand--metabolism
Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. [electronic resource] - Cancer biology & therapy Dec 2009 - 2406-16 p. digital
Publication Type: Journal Article
1555-8576
10.4161/cbt.8.24.10824 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis
Benzenesulfonates--pharmacology
Caspase 3--metabolism
Cell Line, Tumor
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Female
Humans
Lung Neoplasms--metabolism
Mesothelioma--metabolism
Mice
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Transplantation
Niacinamide--analogs & derivatives
Phenylurea Compounds
Phosphorylation
Pleural Neoplasms--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Pyridines--pharmacology
Sorafenib
TNF-Related Apoptosis-Inducing Ligand--metabolism