In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor. [electronic resource]
Producer: 20100304Description: 429-37 p. digitalISSN:- 1097-6809
- Animals
- Apolipoprotein E3 -- genetics
- Atherosclerosis -- enzymology
- Carotid Arteries -- surgery
- Disease Models, Animal
- Electroporation
- Gene Transfer Techniques
- Genetic Therapy -- methods
- Graft Occlusion, Vascular -- enzymology
- Graft Survival
- Humans
- Hypercholesterolemia -- genetics
- Hyperplasia
- Male
- Matrix Metalloproteinases -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Peptide Fragments -- biosynthesis
- Receptors, Urokinase Plasminogen Activator -- metabolism
- Recombinant Fusion Proteins -- biosynthesis
- Time Factors
- Tissue Inhibitor of Metalloproteinase-1 -- biosynthesis
- Urokinase-Type Plasminogen Activator -- biosynthesis
- Venae Cavae -- enzymology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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