In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor.
Eefting, Daniel
In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor. [electronic resource] - Journal of vascular surgery Feb 2010 - 429-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-6809
10.1016/j.jvs.2009.09.026 doi
Animals
Apolipoprotein E3--genetics
Atherosclerosis--enzymology
Carotid Arteries--surgery
Disease Models, Animal
Electroporation
Gene Transfer Techniques
Genetic Therapy--methods
Graft Occlusion, Vascular--enzymology
Graft Survival
Humans
Hypercholesterolemia--genetics
Hyperplasia
Male
Matrix Metalloproteinases--metabolism
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation
Peptide Fragments--biosynthesis
Receptors, Urokinase Plasminogen Activator--metabolism
Recombinant Fusion Proteins--biosynthesis
Time Factors
Tissue Inhibitor of Metalloproteinase-1--biosynthesis
Urokinase-Type Plasminogen Activator--biosynthesis
Venae Cavae--enzymology
In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor. [electronic resource] - Journal of vascular surgery Feb 2010 - 429-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-6809
10.1016/j.jvs.2009.09.026 doi
Animals
Apolipoprotein E3--genetics
Atherosclerosis--enzymology
Carotid Arteries--surgery
Disease Models, Animal
Electroporation
Gene Transfer Techniques
Genetic Therapy--methods
Graft Occlusion, Vascular--enzymology
Graft Survival
Humans
Hypercholesterolemia--genetics
Hyperplasia
Male
Matrix Metalloproteinases--metabolism
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation
Peptide Fragments--biosynthesis
Receptors, Urokinase Plasminogen Activator--metabolism
Recombinant Fusion Proteins--biosynthesis
Time Factors
Tissue Inhibitor of Metalloproteinase-1--biosynthesis
Urokinase-Type Plasminogen Activator--biosynthesis
Venae Cavae--enzymology