Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. [electronic resource]
Producer: 20100602Description: 331-8 p. digitalISSN:- 1878-1705
- Animals
- Anti-Inflammatory Agents
- Biphenyl Compounds
- Blotting, Western
- Cell Survival -- drug effects
- Curcumin -- analogs & derivatives
- Diarylheptanoids
- Down-Regulation -- drug effects
- Inflammation -- chemically induced
- Interleukin-1beta -- biosynthesis
- Lipopolysaccharides -- antagonists & inhibitors
- Macrophage Activation -- drug effects
- Mice
- Microglia -- drug effects
- Mitogen-Activated Protein Kinases -- metabolism
- NF-kappa B -- metabolism
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase Type II -- metabolism
- Nitrites -- metabolism
- Picrates
- Reactive Oxygen Species -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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